PDF Control of the Cell Cycle in Adult Neurogenesis and its Relation Biology Diagrams An inhibition of cyclin-dependent kinases that lengthens, but does not arrest, neuroepithelial cell cycle induces premature neurogenesis. J. Cell Sci. 116, 4947-4955 (2003).
The overall size of the brain is governed by cell cycle machinery. This is clearly demonstrated by the enlarged brains of mice lacking the rather ubiquitous cell cycle inhibitor p27Kip1 Fero et al. 1996, Nakayama et al. 1996.But as some parts of the brain tend to be larger than others, many cell cycle components are expressed in specific areas and control regional growth.
Cell cycle regulation of proliferation versus differentiation in the ... Biology Diagrams
An appreciation of the importance of the Pechnick et al. research necessitates connecting the hypothetical dots between neurogenesis, cell cycle, and antidepressant effects, which this group has accomplished. As for other somatic cells, neuroblast proliferation is regulated during development by a balance of inhibitory and excitatory signals For a long time, it has been understood that neurogenesis is linked to proliferation and thus to the cell cycle. Recently, the gears that mediate this linkage have become accessible to molecular investigation. This review describes some of the progress that has been made in understanding how the molecular machinery of the cell cycle is used in the processes of size regulation in the brain
Keywords: Cell cycle, Differentiation, Neurogenesis, Proneural, Central nervous system. Introduction. During development of the central nervous system (CNS), a period of extensive proliferation is needed to generate the required number of progenitor cells for correct tissue and organ formation. This must be accompanied or closely followed by The advances presented by Pechnick et al. broaden the focus to urge further elucidation of cell cycle and its regulators in adult neurogenesis. Because cell cycle regulators, including p21, also control proliferation and survival of brain tumor stem cells, attempts to consider such regulators as "druggable" therapeutic targets require a
Nature Reviews Molecular Cell Biology Biology Diagrams
For a long time, it has been understood that neurogenesis is linked to proliferation and thus to the cell cycle. Recently, the gears that mediate this linkage have become accessible to molecular investigation. This review describes some of the progress that has been made in understanding how the mol โฆ
